Human acetylcholinesterase (AChE) is a significant target for therapeutic drugs. Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer's disease drug, binds differently to human AChE than it does to Torpedo AChE. These crystals of human AChE provide a more accurate platform for further drug development than previously available.
Representative scheme of ACHE structure and an image from PDBsum server
Databases
PDB-Sum
4EY8 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP
4EY8Fold classification based on Structure-Structure alignment of Proteins - FSSP server
