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Structure Report for: 4A5S

Name|Crystal Structure of human DDP4 in complex with a novel heterocyclic DPP4 inhibitor
Revelation date|08-Feb-2012
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Ostermann, N., Kroemer, M., Zink, F., Gerhartz, B., Sutton, J.M., Clark, S.E., Dunsdon, S.J., Fenton, G., Fillmore, A., Harris, N.V., Higgs, C., Hurley, C.A., Krintel, S.L., MacKenzie, R.E., Duttaroy, A., Gangl, E., Maniara, W., Sedrani, R., Namoto, K., Sirockin, F., Trappe, J., Hassiepen, U., Baeschlin, D.K.
Ligand|Inhibitor: CHEMBL1951424 Ligand in structure: Ligplot


    Title: Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes.
    Sutton JM, Clark DE, Dunsdon SJ, Fenton G, Fillmore A, Harris NV, Higgs C, Hurley CA, Krintel SL and Baeschlin DK <11 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 22:1464, 2012 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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PDB-Sum4A5S Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP4A5S Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP4A5S Structural Classification Of Protein - SCOP server
PROTEOPEDIA4a5s 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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