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Structure Report for: 3VJM

Name|Crystal structure of human dipeptidyl peptidase IV (DPP-4) in complex witha prolylthiazolidine inhibitor 1
Revelation date|15-Aug-2012
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
Gene_locus|human-DPP4
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Akahoshi, F., Kishida, H., Miyaguchi, I., Yoshida, T., Ishii, S.
Ligand|Inhibitor: CHEMBL2058971 Ligand in structure: Ligplot


Reference

    Title: Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group
    Yoshida T, Akahoshi F, Sakashita H, Sonda S, Takeuchi M, Tanaka Y, Nabeno M, Kishida H, Miyaguchi I, Hayashi Y
    Ref: Bioorganic & Medicinal Chemistry, 20:5033, 2012 : PubMed

            

    Title: [(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors
    Yoshida T, Sakashita H, Akahoshi F, Hayashi Y
    Ref: Bioorganic & Medicinal Chemistry Lett, 17:2618, 2007 : PubMed

            

    Title: [(S)-gamma-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors
    Sakashita H, Akahoshi F, Kitajima H, Tsutsumiuchi R, Hayashi Y
    Ref: Bioorganic & Medicinal Chemistry, 14:3662, 2006 : PubMed

            



Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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Databases

PDB-Sum3VJM Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP3VJM Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP3VJM Structural Classification Of Protein - SCOP server
PROTEOPEDIA3vjm 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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