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Structure Report for: 3SWW

Name|Crystal structure of human DPP-IV in complex with SA-(+)-3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyethyl)-2-methyl-5H-pyrrolo[3,4-B]pyridin-7(6H)-one
Revelation date|26-Oct-2011
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Wang, W., Devasthale, P., Wang, A., Harrity, T., Egan, D., Morgan, N., Cap, M., Fura, A., Klei, H.E., Kish, K., Weigelt, C., Sun, L., Levesque, P., Li, Y.X., Zahler, R., Kirby, M.S., Hamann, L.G.
Ligand|Inhibitor: CHEMBL1910114 Ligand in structure: Ligplot


    Title: 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site
    Wang W, Devasthale P, Wang A, Harrity T, Egan D, Morgan N, Cap M, Fura A, Klei HE and Hamann LG <7 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 21:6646, 2011 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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PDB-Sum3SWW Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP3SWW Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP3SWW Structural Classification Of Protein - SCOP server
PROTEOPEDIA3sww 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

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