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Structure Report for: 3Q0T

Name|Crystal structure of human dpp-IV in complex with SA-(+)- methyl2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl- 7-oxo-5H-pyrrolo[3,4-B]pyridin-6(7H)-yl)acetate
Revelation date|29-Feb-2012
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Wang, W., Devasthale, P., Wang, A., Egan, D., Morgan, N., Cap, M., Fura, A., Klei, H.E., Kish, K., Sun, L., Levesque, P., Zahler, R., Kirby, M., Hamann, L.G.
Ligand|Inhibitor: CHEMBL1910111 Ligand in structure: Ligplot


    Title: Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxa mides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors
    Meng W, Brigance RP, Chao HJ, Fura A, Harrity T, Marcinkeviciene J, O'Connor SP, Tamura JK, Xie D and Hamann LG <8 more author(s)>
    Ref: Journal of Medicinal Chemistry, 53:5620, 2010 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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PDB-Sum3Q0T Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP3Q0T Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP3Q0T Structural Classification Of Protein - SCOP server
PROTEOPEDIA3q0t 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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