Tree Display

AceDB Schema

XML Display


Structure Report for: 3OPM

Name|Crystal Structure of Human DPP4 Bound to TAK-294
Revelation date|19-Oct-2011
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Yoshihiro Banno, Yasufumi Miyamoto, Mitsuru Sasaki, Satoru Oi, Tomoko Asakawa, Osamu Kataoka, Koji Takeuchi, Nobuhiro Suzuki, Koji Ikedo, Takuo Kosaka, Shigetoshi Tsubotani, Akiyoshi Tani, Miyuki Funami, Michiko Tawada, Yoshio Yamamoto, Kathleen Aertgeerts, Jason Yano, Hironobu Maezaki
Ligand|Inhibitor: TAK-294 Ligand in structure: Ligplot


    Title: Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554
    Banno Y, Miyamoto Y, Sasaki M, Oi S, Asakawa T, Kataoka O, Takeuchi K, Suzuki N, Ikedo K and Maezaki H <8 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry, 19:4953, 2011 : PubMed


    Title: Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554
    Maezaki H, Banno Y, Miyamoto Y, Moritoh Y, Asakawa T, Kataoka O, Takeuchi K, Suzuki N, Ikedo K and Oi S <9 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry, 19:4482, 2011 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

no Image


PDB-Sum3OPM Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP3OPM Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP3OPM Structural Classification Of Protein - SCOP server
PROTEOPEDIA3opm 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

Acknowledgements and disclaimer