Tree Display

AceDB Schema

XML Display


Structure Report for: 3KWF

Name|human DPP-IV with carmegliptin (S)-1-((2S,3S,11bS)-2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one
Revelation date|12-Jan-2010
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Hennig, M., Stihle, M., Thoma, R.
Ligand|Inhibitor: Carmegliptin Ligand in structure: Ligplot


    Title: Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
    Mattei P, Boehringer M, Di Giorgio P, Fischer H, Hennig M, Huwyler J, Kocer B, Kuhn B, Loeffler BM and Sprecher U <4 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 20:1109, 2010 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

no Image


PDB-Sum3KWF Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP3KWF Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP3KWF Structural Classification Of Protein - SCOP server
PROTEOPEDIA3kwf 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

Acknowledgements and disclaimer