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Structure Report for: 3H0C

Name|Crystal Structure of Human Dipeptidyl Peptidase IV (CD26) in Complex with a Reversed Amide Inhibitor
Revelation date|09-Jun-2009
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Nordhoff, Sonja, Cerezo-Galvez, Silvia, Deppe, Holger, Hill, Oliver, Lopez-Canet, Meritxell, Rummey, Christian, Thiemann, Meinolf, Matassa, Victor G., Edwards, Paul J., Feurer, Achim
Ligand|Inhibitor: FPB-derived-7k Ligand in structure: Ligplot


    Title: Discovery of beta-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV
    Nordhoff S, Cerezo-Galvez S, Deppe H, Hill O, Lopez-Canet M, Rummey C, Thiemann M, Matassa VG, Edwards PJ, Feurer A
    Ref: Bioorganic & Medicinal Chemistry Lett, 19:4201, 2009 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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PDB-Sum3H0C Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP3H0C Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP3H0C Structural Classification Of Protein - SCOP server
PROTEOPEDIA3h0c 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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