A new inhibitor, containing a linked proline-piperidine structure, for the enzyme prolyl oligopeptidase (POP) has been synthesised and demonstrated to bind covalently with the enzyme at the active site. This provides evidence that covalent inhibitors of POP do not have to be limited to structures containing five-membered N-containing heterocyclic rings.
        
Representative scheme of S9N_PPCE_Peptidase_S9 structure and an image from PDBsum server
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Databases
PDB-Sum
2XDW Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP
2XDWFold classification based on Structure-Structure alignment of Proteins - FSSP server