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Structure Report for: 2QOE

Name|Human dipeptidyl peptidase VI in complex with a triazolopiperazine-based beta amino acid inhibitor
Revelation date|06-Nov-2007
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Kowalchick, J.E., Leiting, B., Pryor, K.D., Marsilio, F., Wu, J.K., He, H., Lyons, K.A., Eiermann, G.J., Petrov, A., Scapin, G. et al.
Ligand|Inhibitor: Triazolopiperazine-based-beta-amino-acid Ligand in structure: Ligplot


    Title: Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors
    Kowalchick JE, Leiting B, Pryor KD, Marsilio F, Wu JK, He H, Lyons KA, Eiermann GJ, Petrov A and Kim D <4 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 17:5934, 2007 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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PDB-Sum2QOE Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP2QOE Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP2QOE Structural Classification Of Protein - SCOP server
PROTEOPEDIA2qoe 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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