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Structure Report for: 2IIT

Name|Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor
Revelation date|28-Nov-2006
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Biftu, T., Feng, D., Qian, X., Linag, G.-B., Kieczykowsky, G., Eiermann, G., He, H., Leiting, B., Lyons, K.A., Petrov, A., Sinha-Roy, R., Zhang, B., Scapin, G., Patel, S.B.., Gao, Y-D., Singh, S., Wu, J., Zhang, X., Thornberry, N.A., Weber, A.E.
Ligand|Inhibitor: Diazepanone-Analog-1 Ligand in structure: Ligplot


    Title: (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)- 1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
    Biftu T, Feng D, Qian X, Liang GB, Kieczykowski G, Eiermann G, He H, Leiting B, Lyons K and Weber AE <10 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 17:49, 2007 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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PDB-Sum2IIT Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP2IIT Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP2IIT Structural Classification Of Protein - SCOP server
PROTEOPEDIA2iit 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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