Structure Report for: 2AJL

Qiao, L., Baumann, C.A., Crysler, C.S., Ninan, N.S., Abad, M.C., Spurlino, J.C., Desjarlais, R.L., Kervinen, J., Neeper, M.P., Bayoumy, S.S., Williams, R., Deckman, I.C., Dasgupta, M., Reed, R.L., Huebert, N.D., Tomczuk, B.E., Moriarty, K.J.

Title: Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors
Qiao L, Baumann CA, Crysler CS, Ninan NS, Abad MC, Spurlino JC, Desjarlais RL, Kervinen J, Neeper MP and Moriarty KJ <7 more author(s)> Qiao L, Baumann CA, Crysler CS, Ninan NS, Abad MC, Spurlino JC, Desjarlais RL, Kervinen J, Neeper MP, Bayoumy SS, Williams R, Deckman IC, Dasgupta M, Reed RL, Huebert ND, Tomczuk BE, Moriarty KJ (- 7)
Ref: Bioorganic & Medicinal Chemistry Lett, 16:123, 2006 : PubMed
Abstract


ESTHER: Qiao_2006_Bioorg.Med.Chem.Lett_16_123
PubMedSearch: Qiao 2006 Bioorg.Med.Chem.Lett 16 123
PubMedID: 16236500
Gene_locus related to this paper: human-DPP4
Inhibitor(s) related to this paper: JNH, p-Iodo-Phe-Pyr-CN

Abstract

The discovery, SAR, and X-ray crystal structure of novel biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported.