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Structure Report for: 1W76

Name|Orthorhombic form of Torpedo californica acetylcholinesterase ( AChE) complexed with bis-acting galanthamine derivative
Revelation date|25-Nov-2004
Family|ACHE: there are 543 genes in this family, 316 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Greenblatt, H.M., Guillou, C., Guenard, D., Badet, B., Thal, C., Silman, I., Sussman, J.L
Ligand|Inhibitor: Galanthamine Ligand in structure: Ligplot


    Title: The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design
    Greenblatt HM, Guillou C, Guenard D, Argaman A, Botti SA, Badet B, Thal C, Silman I, Sussman JL
    Ref: Journal of the American Chemical Society, 126:15405, 2004 : PubMed


Representative scheme of ACHE structure and an image from PDBsum server


PDB-Sum1W76 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP1W76 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP1W76 Structural Classification Of Protein - SCOP server
PROTEOPEDIA1w76 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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