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Structure Report for: 1RWQ

Name|Human Dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-pyrimidin-4-amine
Revelation date|17-Dec-2004
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Hennig, M., Thoma, R., Stihle, M.
Ligand|Inhibitor: 5AP Ligand in structure: Ligplot


    Title: Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents
    Peters JU, Weber S, Kritter S, Weiss P, Wallier A, Boehringer M, Hennig M, Kuhn B, Loeffler BM
    Ref: Bioorganic & Medicinal Chemistry Lett, 14:1491, 2004 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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PDB-Sum1RWQ Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP1RWQ Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP1RWQ Structural Classification Of Protein - SCOP server
PROTEOPEDIA1rwq 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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