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Structure Report for: 1ODC

Name|Acetylcholinesterase complexed with N-4'-quinolyl-N'-9-(1,2,3,4-tetrahydroacridinyl)-1,8-diaminooctane at 2.2A resolution
Revelation date|23-Mar-2005
Family|ACHE: there are 543 genes in this family, 316 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Wong, D.M., Greenblatt, H.M., Shaya, D., Carlier, P.R., Han, Y.F., Pang, Y.P., Silman, I., Sussman, J.L.
Ligand|Inhibitor: Tacrine(8)-4-aminoquinoline Ligand in structure: Ligplot


    Title: Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge
    Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL
    Ref: Journal of Medicinal Chemistry, 49:5491, 2006 : PubMed


Representative scheme of ACHE structure and an image from PDBsum server


PDB-Sum1ODC Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP1ODC Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP1ODC Structural Classification Of Protein - SCOP server
PROTEOPEDIA1odc 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

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