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Structure Report for: 1AMN

Name|Torpedo acetylcholinesterase complexed with transition state analog with m-(N,N,N-trimethyammonio)trifluoroacetophenone (TMTFA, NAF)
Revelation date|03-Apr-1996
Family|ACHE: there are 543 genes in this family, 316 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
TMTFA is an equilibrium mixture of the free ketone and ketone hydrate NAF in aqueous solution, with a hydration equilibrium constant of 60 000
Ligand|Inhibitor: TMTFA Ligand in structure: Ligplot Inhibitor: NAF Ligand in structure: Ligplot


    Title: A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase
    Silman I, Millard CB, Ordentlich A, Greenblatt HM, Harel M, Barak D, Shafferman A, Sussman JL
    Ref: Chemico-Biological Interactions, 119-120:43, 1999 : PubMed


    Title: The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase.
    Harel M, Quinn DM, Nair HK, Silman I, Sussman JL
    Ref: Journal of the American Chemical Society, 118:2340, 1996 : PubMed


Representative scheme of ACHE structure and an image from PDBsum server


PDB-Sum1AMN Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP1AMN Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP1AMN Structural Classification Of Protein - SCOP server
PROTEOPEDIA1amn 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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