Name : Torpedo acetylcholinesterase complexed with transition state analog with m-(N,N,N-trimethyammonio)trifluoroacetophenone (TMTFA, NAF)
Revelation date : 03-Apr-1996
Family : ACHE
Gene_locus : torca-ACHE
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
TMTFA is an equilibrium mixture of the free ketone and ketone hydrate NAF in aqueous solution, with a hydration equilibrium constant of 60 000
Ligand : 02
Title : A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase - Silman_1999_Chem.Biol.Interact_119-120_43 |
Author(s) : Silman I , Millard CB , Ordentlich A , Greenblatt HM , Harel M , Barak D , Shafferman A , Sussman JL |
Ref : Chemico-Biological Interactions , 119-120 :43 , 1999 |
Abstract : Silman_1999_Chem.Biol.Interact_119-120_43 |
ESTHER : Silman_1999_Chem.Biol.Interact_119-120_43 |
PubMedSearch : Silman_1999_Chem.Biol.Interact_119-120_43 |
PubMedID: 10421437 |
Gene_locus related to this paper: torca-ACHE |
Title : The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase. - |
Author(s) : Harel M , Quinn DM , Nair HK , Silman I , Sussman JL |
Ref : Journal of the American Chemical Society , 118 :2340 , 1996 |
PubMedID: |
Gene_locus related to this paper: torca-ACHE |