8E5W
Name : 2.1 angstrom crystal structure of the Mycobacterium tuberculosis serine hydrolase, Hip1, in its anhydro-form (Anhydrohip1). dehydroalanine Hip1
Revelation date : 07-Dec-2022
Family : Tiancimycin-TnmK-Tripeptidase-HIP
Gene_locus : myctu-ym24
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Ostrov, D.A., Li, D. || No electron density for the inhibitor in the omit map for the Hip1-AEBSF complex. Rather, in the active site, dehydroalanine (dAla) was found to occupy the expected position of the catalytic Ser228, thus yielding anhydrohip1
Ligand :
References (1)
| Title : 2.1 A crystal structure of the Mycobacterium tuberculosis serine hydrolase, Hip1, in its anhydro-form (Anhydrohip1) - Brooks_2022_Biochem.Biophys.Res.Commun_630_57 |
| Author(s) : Brooks CL , Ostrov DA , Schumann NC , Kakkad S , Li D , Pena K , Williams BP , Goldfarb NE |
| Ref : Biochemical & Biophysical Research Communications , 630 :57 , 2022 |
| Abstract : Brooks_2022_Biochem.Biophys.Res.Commun_630_57 |
| ESTHER : Brooks_2022_Biochem.Biophys.Res.Commun_630_57 |
| PubMedSearch : Brooks_2022_Biochem.Biophys.Res.Commun_630_57 |
| PubMedID: 36148729 |
| Gene_locus related to this paper: myctu-ym24 |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
