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Structure Report for: 7AMZ

Name|Human butyrylcholinesterase in complexe with N-((2S,3R)-3-hydr oxy-4-(neopentylamino)-1-phenylbutan-2-yl)-2,2-diphenylacetamide (51)
Revelation date|26-May-2021
Family|BCHE: there are 91 genes in this family, 92 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Ligand|Inhibitor: MTDL-cpd51-diphenylacetamide Ligand in structure: Ligplot


    Title: Discovery of multifunctional anti-Alzheimers agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters
    Pasieka A, Panek D, Jonczyk J, Godyn J, Szalaj N, Latacz G, Tabor J, Mezeiova E, Chantegreil F and Malawska B <10 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 218:113397, 2021 : PubMed


Representative scheme of BCHE structure and an image from PDBsum server


PDB-Sum7AMZ Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP7AMZ Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP7AMZ Structural Classification Of Protein - SCOP server
PROTEOPEDIA7amz 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

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