5KRE
Name : Crystal Structure of human LYLPLAL1 with a covalent inhibitor
Revelation date : 20-Jul-2016
Family : LYsophospholipase_carboxylesterase
Gene_locus : human-LYPLAL1
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
N1-substituted triazole urea previously disclosed as an inhibitor of ABHD6 KT195<\/A> was modified as N2-substituted isomer and shown to inhibit LYPLAL1. The compound 2 inhibited also other alpha\/beta hydrolases and some SGNH hydrolase-type esterase (PAFAH1B2-3), but compound 11 and 12 are specific. The adduct in the structure is the small (R)-2-phenylpiperidine-1-carbonyl
Ligand :
References (1)
| Title : Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism - Ahn_2016_ACS.Chem.Biol_11_2529 |
| Author(s) : Ahn K , Boehm M , Brown MF , Calloway J , Che Y , Chen J , Fennell KF , Geoghegan KF , Gilbert AM , Gutierrez JA , Kalgutkar AS , Lanba A , Limberakis C , Magee TV , O'Doherty I , Oliver R , Pabst B , Pandit J , Parris K , Pfefferkorn JA , Rolph TP , Patel R , Schuff B , Shanmugasundaram V , Starr JT , Varghese AH , Vera NB , Vernochet C , Yan J |
| Ref : ACS Chemical Biology , 11 :2529 , 2016 |
| Abstract : Ahn_2016_ACS.Chem.Biol_11_2529 |
| ESTHER : Ahn_2016_ACS.Chem.Biol_11_2529 |
| PubMedSearch : Ahn_2016_ACS.Chem.Biol_11_2529 |
| PubMedID: 27391855 |
| Gene_locus related to this paper: human-LYPLAL1 |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
