Name : Human acetylcholinesterase designed variant expressed in bacteria
Revelation date : 27-Jul-2016
Family : ACHE
Gene_locus : human-ACHE
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Goldenzweig, A., Goldsmith, M., Hill, S.E., Gertman, O., Laurino, P.,
Ashani, Y., Dym, O., Albeck, S., Unger, T., Prilusky, J., Lieberman, R.L.,
Aharoni, A., Silman, I., Sussman, J.L., Tawfik, D.S., Fleishman, S.J. (51 substitutions)
(V12T,K23T,M42V,L48R,V60W,S67N,E91N,T109K,S110N,T112A,L115M,A127S,Q140R,A141T,
T144V,V187I,V226I,G234A,T238Y,G240S,M241R,G242E,T249L,H253K,T275N,A278P,
V280E,S309P,A318N,H322K,V331N,Q325D,A357E,A361E,V378I,R393K,L394N,E396D,V408I,
L414F,G416Q,L418Y,Q421N,A434S,S438P,L441E,A467K,Q474R,G506D,A507E,Q509K)
>5HQ3
MEGREDAELLVTTRGGRLRGIRLTTPGGPVSAFLGIPFAEPPVGPRRFRPPEPKQPWSGVWDATTFQNVCYQYVDTLYPG
FEGTEMWNPNRNLSEDCLYLNVWTPYPRPKNPAPVMVWIYGGGFYSGSSSLDVYDGRFLVRTERVVLVSMNYRVGAFGFL
ALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAILQSGAPNAPWAYV
SREEARRRALQLAKLVGCPPGGTGGNDTELVACLRNRPPQELVNHEWHVLPQESVFRFSFVPVVDGDFLPDTPEALINNG
DFKGLDVLVGVNKDEGSYFLVYGAPGFSKDNESLISREEFLEGVRVGVPQVSDLAAEAIVLHYTDWLHPEDPAKNRDALS
DVVGDHNVICPVAQFAQRYAANGARVYAYVFEHRSSTLPWPEWMGVPHGYEIEFIFGIPLDPSRNYTKEEKIFARRLMRY
WANFARTGDPNEPRDPKAPQWPPYTADEQKYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLD
Ligand :
Title : Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability - Goldenzweig_2016_Mol.Cell_63_337 |
Author(s) : Goldenzweig A , Goldsmith M , Hill SE , Gertman O , Laurino P , Ashani Y , Dym O , Unger T , Albeck S , Prilusky J , Lieberman RL , Aharoni A , Silman I , Sussman JL , Tawfik DS , Fleishman SJ |
Ref : Mol Cell , 63 :337 , 2016 |
Abstract : Goldenzweig_2016_Mol.Cell_63_337 |
ESTHER : Goldenzweig_2016_Mol.Cell_63_337 |
PubMedSearch : Goldenzweig_2016_Mol.Cell_63_337 |
PubMedID: 27425410 |
Gene_locus related to this paper: human-ACHE |