Name : Crystal structure of human mono-glyceride lipase in complex with SAR127303
Revelation date : 21-Jan-2015
Family : Monoglyceridelipase_lysophospholip
Gene_locus : human-MGLL
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Griebel, G., Pichat, P., Beeske, S., Leroy, T., Redon, N., Francon, D., Bert, L., Even, L., Lopez-Grancha, M., Tolstykh, T., Sun, F., Yu, Q., Brittain, S., Arlt, H., He, T., Zhang, B., Wiederschain, D., Bertrand, T., Houtman, J., Rak, A., Vallee, F., Michot, N., Auge, F., Menet, V., Bergis, O.E., George, P., Avenet, P., Mikol, V., Didier, M., Escoubet, J.
Ligand :
Title : Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents - Griebel_2015_Sci.Rep_5_7642 |
Author(s) : Griebel G , Pichat P , Beeske S , Leroy T , Redon N , Jacquet A , Francon D , Bert L , Even L , Lopez-Grancha M , Tolstykh T , Sun F , Yu Q , Brittain S , Arlt H , He T , Zhang B , Wiederschain D , Bertrand T , Houtmann J , Rak A , Vallee F , Michot N , Auge F , Menet V , Bergis OE , George P , Avenet P , Mikol V , Didier M , Escoubet J |
Ref : Sci Rep , 5 :7642 , 2015 |
Abstract : Griebel_2015_Sci.Rep_5_7642 |
ESTHER : Griebel_2015_Sci.Rep_5_7642 |
PubMedSearch : Griebel_2015_Sci.Rep_5_7642 |
PubMedID: 25560837 |
Gene_locus related to this paper: mouse-ABHD6 |
Title : Structural basis for human monoglyceride lipase inhibition - Bertrand_2010_J.Mol.Biol_396_663 |
Author(s) : Bertrand T , Auge F , Houtmann J , Rak A , Vallee F , Mikol V , Berne PF , Michot N , Cheuret D , Hoornaert C , Mathieu M |
Ref : Journal of Molecular Biology , 396 :663 , 2010 |
Abstract : Bertrand_2010_J.Mol.Biol_396_663 |
ESTHER : Bertrand_2010_J.Mol.Biol_396_663 |
PubMedSearch : Bertrand_2010_J.Mol.Biol_396_663 |
PubMedID: 19962385 |
Gene_locus related to this paper: human-MGLL |