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Structure Report for: 4TPK

Name|Human butyrylcholinesterase in complex with N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-methoxyethyl)-2-naphthamide
Revelation date|22-Oct-2014
Family|BCHE: there are 91 genes in this family, 92 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Brus, B., Kosak U, Stojan, J., Turk, S., Pislar, A., Coquelle, N., Colletier, J.P., Kos, J., Gobec, S.
Ligand|Inhibitor: 3F9 Ligand in structure: Ligplot


    Title: Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor
    Brus B, Kosak U, Turk S, Pislar A, Coquelle N, Kos J, Stojan J, Colletier JP, Gobec S
    Ref: Journal of Medicinal Chemistry, 57:8167, 2014 : PubMed


Representative scheme of BCHE structure and an image from PDBsum server


PDB-Sum4TPK Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP4TPK Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP4TPK Structural Classification Of Protein - SCOP server
PROTEOPEDIA4tpk 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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