Compound 4 is as efficient as HI-6 for VX-hAChE, while3 equals trimedoxime for tabun-hAChE.In comparison with pralidoxime,3 and 4 are up to 30-fold more efficient for VX-AChE, up to 60-fold more efficient for tabun-AChE and up to 10-fold more efficient for paraoxon-AChE
Title: Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases Renou J, Loiodice M, Arboleas M, Baati R, Jean L, Nachon F, Renard PY Ref: Chem Commun (Camb), 50:3947, 2014 : PubMed
Two promising uncharged reactivators for inhibited human BChE and AChE have been described. These compounds show an ability to reactivate VX-inhibited BChE largely superior to those of known pyridinium aldoximes. Moreover, these oximes also exhibit a good ability to reactivate VX-, tabun- and paraoxon-inhibited human AChE.
