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Reactivator Report for: K048

General
Type Bispyridinium, Oxime
Chemical_Nomenclature [1-[4-(4-carbamoylpyridin-1-ium-1-yl)butyl]pyridin-4-ylidene]methyl-oxoazanium
Canonical SMILES C1=CN(C=CC1=C[NH+]=O)CCCC[N+]2=CC=C(C=C2)C(=O)N
InChI InChI=1S/C16H18N4O2/c17-16(21)15-5-11-20(12-6-15)8-2-1-7-19-9-3-14(4-10-19)13-18-22/h3-6,9-13H,1-2,7-8H2,(H-,17,21)/p+2
InChIKey KMFIVIQDYRPBBJ-UHFFFAOYSA-P
Other name(s) 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide ; K-48 ; CHEMBL1180193
________________________________________________________________________________________________
MW|300.35
Formula|C16H20N4O2
CAS_number|
PubChem|90659972
UniChem|KMFIVIQDYRPBBJ-UHFFFAOYSA-P
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: K048

20 more
    Title: Determination of K869, a novel oxime reactivator of acetylcholinesterase, in rat body fluids and tissues by liquid-chromatography methods: Pharmacokinetic study
    Vanova N, Hojna A, Pejchal J, Herman D, Malinak D, Prchalova E, Musilek K, Karasova JZ
    Ref: J Pharm Sci, :, 2021 : PubMed

            

    Title: The Experimental Oxime K027-A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime
    Lorke DE, Petroianu GA
    Ref: Front Neurosci, 13:427, 2019 : PubMed

            

    Title: Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase
    Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Opletalova V, Dolezal M
    Ref: J Enzyme Inhib Med Chem, 23:70, 2008 : PubMed

            


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