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Reactivator Report for: 6-Alkyl-3-Fluoro-2-pyridinaldoxime-12d

compound 12d greater affinity and higher reactivation efficiency(kr2=83 mm-1.min-1) than 2-PAM and HI-6.Compound 12d seven times more efficient in the reactivation of sarin-inhibited AChE compared with 2-PAM,and six times more efficient than HI-6. Compound12d completely inefficient in reactivating tabun-inhibited hAChE


General
Type Pyridine, Oxime, Pyridine-aldoxime
Chemical_Nomenclature N-[[3-fluoro-6-(2-pyridin-3-ylethyl)pyridin-2-yl]methylidene]hydroxylamine
Canonical SMILES C1=CC(=CN=C1)CCC2=NC(=C(C=C2)F)C=NO
InChI InChI=1S/C13H12FN3O/c14-12-6-5-11(17-13(12)9-16-18)4-3-10-2-1-7-15-8-10/h1-2,5-9,18H,3-4H2
InChIKey CKUUWPBCPYJLIA-UHFFFAOYSA-N
Other name(s)
________________________________________________________________________________________________
MW|245.25
Formula|C13H12FN3O
CAS_number|
PubChem|138559949
UniChem|CKUUWPBCPYJLIA-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: 6-Alkyl-3-Fluoro-2-pyridinaldoxime-12d
    Title: Chemoselective Hydrogenation of 6-Alkynyl-3-fluoro-2-pyridinaldoximes: Access to First-in-Class 6-Alkyl-3-Fluoro-2-pyridinaldoxime Scaffolds as New Reactivators of Sarin-Inhibited Human Acetylcholinesterase with Increased Blood-Brain Barrier Permeability
    Yerri J, Dias J, Nimmakayala MR, Razafindrainibe F, Courageux C, Gastellier AJ, Jegoux J, Coisne C, Landry C and Baati R <5 more author(s)>
    Ref: Chemistry, 26:15035, 2020 : PubMed

            


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