Two new lappaconitine-type C18-diterpenoid alkaloids, named as leucostosines C (1) and D (2), together with six known compounds (3-8), were isolated from the roots of Aconitum leucostomum Worosch. Their structures were elucidated by various spectroscopic analyses, including IR, HR-ESI-MS, NMR spectra and X-ray experiments. Leucostosine C is the first diterpenoid alkaloid bearing the 7-amino group. The isolated compounds were tested for the acetylcholinesterase (AChE) inhibitory effect and neuroprotective activity, none of them showed significant activities.
        
Related information
Citations formats
Zhou X, Yang HB, Luo YY, Xu JB, Liu Y, Gao F, Huang S, Chen L (2022) Two new C18-diterpenoid alkaloids from Aconitum leucostomum Worosch Chem Biodivers
Zhou X, Yang HB, Luo YY, Xu JB, Liu Y, Gao F, Huang S, Chen L (2022) Chem Biodivers