Title: Evaluation of the effect of high protein supply on diaphragm atrophy in critically ill patients receiving prolonged mechanical ventilation Zhang Q, Zhou J, Zhu D, Zhou S Ref: Nutr Clin Pract, :, 2021 : PubMed
BACKGROUND: Our aim was to evaluate the effect of high protein to the target of 2.0 g/kg/d on diaphragm atrophy and clinical prognosis of patients receiving prolonged mechanical ventilation (MV). METHODS: This prospective, randomized, controlled, single-center study included 41 patients who were treated with <=7 days' MV. The patients were randomly divided into a standard nutrition treatment (SNT) group and intensive nutrition treatment (INT) group, followed by evaluation of computer tomography-analyzed diaphragm volume, the level of butyrylcholinesterase (BChE) as a muscle mass indicator, and respiratory mechanics indices weekly to observe and compare the differences between the groups. RESULTS: In the INT group, the actual protein (1.70 +/- 0.21 vs 1.06 +/- 0.21 g/kg/d, P < .001) and calorie intake (33.46 +/- 2.78 vs 25.75 +/- 4.81 kcal/kg/d, P < .001) were significantly different from those of the SNT group. Compared with the SNT group, the INT group's diaphragm atrophy improved in the fourth and fifth weeks (all P < .05). The BChE after the third week was higher (all P < .05). No significant differences in respiratory mechanical indices and clinical outcomes were found in the surviving patients between the groups. CONCLUSION: INT improved the diaphragm atrophy and muscle mass of critically ill patients receiving prolonged MV. There was no evidence that increasing protein to the target amount of 2.0 g/kg/d is related to improvement in clinical prognosis for patients receiving prolonged MV.
        
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Zhang Q, Zhou J, Zhu D, Zhou S (2021) Evaluation of the effect of high protein supply on diaphragm atrophy in critically ill patients receiving prolonged mechanical ventilation Nutr Clin Pract
Zhang Q, Zhou J, Zhu D, Zhou S (2021) Nutr Clin Pract