Paper Report for: Zhang_2010_Biotechnol.Lett_32_513
Reference
Title: Bio-resolution of glycidyl (o, m, p)-methylphenyl ethers by Bacillus megaterium Zhang Z, Sheng Y, Jiang K, Wang Z, Zheng Y, Zhu Q Ref: Biotechnol Lett, 32:513, 2010 : PubMed
A newly isolated Bacillus megaterium with epoxide hydrolase activity resolved racemic glycidyl (o, m, p)-methylphenyl ethers to give enantiopure epoxides in 84-99% enantiomeric excess and with 21-73 enantiomeric ratios. The (S)-enantiomer was obtained from rac-glycidyl (o or m)-methylphenyl ether while the (R)-epoxides was obtained from glycidyl p-methylphenyl ether. The observations are explained at the level by enzyme-substrate docking studies.
Zhang Z, Sheng Y, Jiang K, Wang Z, Zheng Y, Zhu Q (2010) Bio-resolution of glycidyl (o, m, p)-methylphenyl ethers by Bacillus megaterium Biotechnol Lett32: 513-6
Zhang Z, Sheng Y, Jiang K, Wang Z, Zheng Y, Zhu Q (2010) Biotechnol Lett32: 513-6