Paper Report for: Xu_2006_Bioorg.Med.Chem.Lett_16_5373 Reference
Title: Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors
Xu J , Wei L , Mathvink RJ , Edmondson SD , Eiermann GJ , He H , Leone JF , Leiting B , Lyons KA and Weber AE <7 more author(s)>
Xu J , Wei L , Mathvink RJ , Edmondson SD , Eiermann GJ , He H , Leone JF , Leiting B , Lyons KA , Marsilio F , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE (- 7)
Ref: Bioorganic & Medicinal Chemistry Lett,
16 :5373, 2006 :
PubMed Abstract PubMedSearch: Xu 2006 Bioorg.Med.Chem.Lett 16 5373 PubMedID: 16919457 Gene_locus related to this paper: human-DPP4 Inhibitor(s) related to this paper: 3TP Abstract
A novel series of oxadiazole based amides have been shown to be potent DPP-4 inhibitors. The optimized compound 43 exhibited excellent selectivity over a variety of DPP-4 homologs.
        
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Citations formats
Xu J, Wei L, Mathvink RJ, Edmondson SD, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE (2006) Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitorsBioorganic & Medicinal Chemistry Lett 16 : 5373-7 Xu J, Wei L, Mathvink RJ, Edmondson SD, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE (2006) Bioorganic & Medicinal Chemistry Lett 16 : 5373-7