Title : 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site - Wang_2011_Bioorg.Med.Chem.Lett_21_6646 |
Author(s) : Wang W , Devasthale P , Wang A , Harrity T , Egan D , Morgan N , Cap M , Fura A , Klei HE , Kish K , Weigelt C , Sun L , Levesque P , Li YX , Zahler R , Kirby MS , Hamann LG |
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :6646 , 2011 |
Abstract : Wang_2011_Bioorg.Med.Chem.Lett_21_6646 |
ESTHER : Wang_2011_Bioorg.Med.Chem.Lett_21_6646 |
PubMedSearch : Wang_2011_Bioorg.Med.Chem.Lett_21_6646 |
PubMedID: 21996520 |
Gene_locus related to this paper: human-DPP4 |
Gene_locus related to this paper: human-DPP4 |
Wang W, Devasthale P, Wang A, Harrity T, Egan D, Morgan N, Cap M, Fura A, Klei HE, Kish K, Weigelt C, Sun L, Levesque P, Li YX, Zahler R, Kirby MS, Hamann LG (2011)
7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site
Bioorganic & Medicinal Chemistry Lett
21 :6646
Wang W, Devasthale P, Wang A, Harrity T, Egan D, Morgan N, Cap M, Fura A, Klei HE, Kish K, Weigelt C, Sun L, Levesque P, Li YX, Zahler R, Kirby MS, Hamann LG (2011)
Bioorganic & Medicinal Chemistry Lett
21 :6646