Paper Report for: Wallace_2008_Bioorg.Med.Chem.Lett_18_2362 Reference
Title: Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors
Wallace MB , Feng J , Zhang Z , Skene RJ , Shi L , Caster CL , Kassel DB , Xu R , Gwaltney SL, 2nd
Ref: Bioorganic & Medicinal Chemistry Lett,
18 :2362, 2008 :
PubMed Abstract PubMedSearch: Wallace 2008 Bioorg.Med.Chem.Lett 18 2362 PubMedID: 18346892 Gene_locus related to this paper: human-DPP4 Inhibitor(s) related to this paper: 2-phenylbenzylamine ,
Benzimidazole-derivative-2 Abstract
A novel series of non-covalent, benzimidazole-based inhibitors of DPP-4 has been developed from a small fragment hit using structure-based drug design. A highly versatile synthetic route was created for the development of SAR, which led to the discovery of potent and selective inhibitors with excellent pharmaceutical properties.
        
Citations formats
Wallace MB, Feng J, Zhang Z, Skene RJ, Shi L, Caster CL, Kassel DB, Xu R, Gwaltney SL, 2nd (2008) Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitorsBioorganic & Medicinal Chemistry Lett 18 : 2362-7 Wallace MB, Feng J, Zhang Z, Skene RJ, Shi L, Caster CL, Kassel DB, Xu R, Gwaltney SL, 2nd (2008) Bioorganic & Medicinal Chemistry Lett 18 : 2362-7