Paper Report for: Varoqueaux_2004_Eur.J.Cell.Biol_83_449
Reference
Title: Neuroligin 2 is exclusively localized to inhibitory synapses Varoqueaux F, Jamain S, Brose N Ref: European Journal of Cell Biology, 83:449, 2004 : PubMed
Neuroligins are cell adhesion proteins that are thought to instruct the formation and alignment of synaptic specializations. The three known rodent neuroligin isoforms share homologous extracellular acetylcholinesterase-like domains that bridge the synaptic cleft and bind beta-neurexins. All neuroligins have identical intracellular C-terminal motifs that bind to PDZ domains of various target proteins. Neuroligin 1 is specifically localized to glutamatergic postsynaptic specializations. We show here that neuroligin 2 is exclusively localized to inhibitory synapses in rat brain and dissociated neurons. In immature neurons, neuroligin 2 is found at synapses and also at GABAA receptor aggregates that are not facing presynaptic termini, indicating that postsynaptic mechanisms lead to synaptic recruitment of neuroligin 2. Our findings identify neuroligin 2 as a new cell adhesion protein specific for inhibitory synapses and open new avenues for identifiying the constituents of this unique type of postsynaptic specialization.
        
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Varoqueaux F, Jamain S, Brose N (2004) Neuroligin 2 is exclusively localized to inhibitory synapses European Journal of Cell Biology83: 449-56
Varoqueaux F, Jamain S, Brose N (2004) European Journal of Cell Biology83: 449-56