Paper Report for: Si_1994_Zhonghua.Nei.Ke.Za.Zhi_33_583
Reference
Title: [Experimental research on treatment of acute organophosphorus insecticides poisoning with high-dose atropine: upregulation of muscarinic receptor]. [Chinese] Si FZ, Wang DX, Yang GQ Ref: Chinese Journal of Internal Medicine, 33:583, 1994 : PubMed
Acute organophosphorus insecticides poisoning (AOIP) is a common medical emergency. There is, at present, a tendency to use high-dose atropine treatment (HDAT). This study aims to test if, during AOIP, HDAT would cause upregulation of muscarinic receptor (M-R). Male mice of the same batch and strain were raised, randomly divided into 3 groups and orally fed with DDVP of the same dose. HDAT for 7 days was given to group A, HDAT for 36 hours was given to group B and low-dose atropine treatment for 36 hours was given to group C. Then radionuclide assay was employed to measure the M-R in the brain and atrium of the mice in each group. The results were that, compared with a control group, the Bmax values (fmol.mg protein-1) of M-R in groups A and B were increased significantly (P < 0.01), while that in group C showed no evident change (P > 0.05). These results indicate that HDAT leads to some physiological change in the body, which may be responsible for the development of poisoning rebound and atropine dependence.
Si FZ, Wang DX, Yang GQ (1994) [Experimental research on treatment of acute organophosphorus insecticides poisoning with high-dose atropine: upregulation of muscarinic receptor]. [Chinese] Chinese Journal of Internal Medicine33: 583-6
Si FZ, Wang DX, Yang GQ (1994) Chinese Journal of Internal Medicine33: 583-6
