Paper Report for: Shuai_2019_Future.Med.Chem_11_2687
Reference
Title: Design, synthesis and molecular modeling of isothiochromanone derivatives as acetylcholinesterase inhibitors Shuai W, Li W, Yin Y, Yang L, Xu F, Xu S, Yao H, Zhu Z, Xu J Ref: Future Med Chem, 11:2687, 2019 : PubMed
Aim: A series of novel isothio- and isoselenochromanone derivatives bearing N-benzyl pyridinium moiety were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors. Results: Most of the target compounds exhibited potent anti-AChE activities with IC50 values in nanomolar ranges. Among them, compound 15a exhibited the most potent anti-AChE activity (IC50 = 2.7 nM), moderate antioxidant activity and low neurotoxicity. Moreover, the kinetic and docking studies revealed that compound 15a was a mixed-type inhibitor, which bounds to peripheral anionic site and catalytic active site of AChE. Conclusion: Those results suggested that compound 15a might be a potential candidate for AD treatment.
        
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Shuai W, Li W, Yin Y, Yang L, Xu F, Xu S, Yao H, Zhu Z, Xu J (2019) Design, synthesis and molecular modeling of isothiochromanone derivatives as acetylcholinesterase inhibitors Future Med Chem11: 2687-2699
Shuai W, Li W, Yin Y, Yang L, Xu F, Xu S, Yao H, Zhu Z, Xu J (2019) Future Med Chem11: 2687-2699