Paper Report for: Sheng_2005_Bioorg.Med.Chem.Lett_15_3834
Reference
Title: Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors Sheng R, Lin X, Li J, Jiang Y, Shang Z, Hu Y Ref: Bioorganic & Medicinal Chemistry Lett, 15:3834, 2005 : PubMed
A series of 2-phenoxy-indan-1-one derivatives have been designed, synthesized, and tested as acetylcholinesterase inhibitors. The most potent compound exhibited high AChE inhibitory activity (IC50 = 50 nM), and the molecular docking study indicated that it was nicely accommodated by AChE.
Sheng R, Lin X, Li J, Jiang Y, Shang Z, Hu Y (2005) Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors Bioorganic & Medicinal Chemistry Lett15: 3834-7
Sheng R, Lin X, Li J, Jiang Y, Shang Z, Hu Y (2005) Bioorganic & Medicinal Chemistry Lett15: 3834-7