Paper Report for: Shao_2004_Bioorg.Med.Chem.Lett_14_4639
Reference
Title: Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease Shao D, Zou C, Luo C, Tang X, Li Y Ref: Bioorganic & Medicinal Chemistry Lett, 14:4639, 2004 : PubMed
Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's disease were assayed. The optimum hybrid inhibitor 3 is 37-fold more potent and 31-fold more selective than tacrine in vitro.
Shao D, Zou C, Luo C, Tang X, Li Y (2004) Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease Bioorganic & Medicinal Chemistry Lett14: 4639-42
Shao D, Zou C, Luo C, Tang X, Li Y (2004) Bioorganic & Medicinal Chemistry Lett14: 4639-42