Title: Building and destroying synaptic bridges: How do Hevin/Sparcl1, SPARC, and MDGAs modify trans-synaptic neurexin-neuroligin interactions? Ramirez JJ, Bindu DS, Eroglu C Ref: Structure, 29:635, 2021 : PubMed
Astrocyte-secreted Hevin induces synapse formation by bridging the trans-synaptic organizers, neuroligins and neurexins. In this issue of Structure, Fan et al. (2021) elucidate the structural basis of Hevin's interaction with these molecules and reveal the competitive interplay between Hevin, SPARC, and MDGAs.
        
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Ramirez JJ, Bindu DS, Eroglu C (2021) Building and destroying synaptic bridges: How do Hevin/Sparcl1, SPARC, and MDGAs modify trans-synaptic neurexin-neuroligin interactions? Structure29: 635-637
Ramirez JJ, Bindu DS, Eroglu C (2021) Structure29: 635-637