Paper Report for: Qiao_2006_Bioorg.Med.Chem.Lett_16_123 Reference
Title: Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors
Qiao L , Baumann CA , Crysler CS , Ninan NS , Abad MC , Spurlino JC , Desjarlais RL , Kervinen J , Neeper MP and Moriarty KJ <7 more author(s)>
Qiao L , Baumann CA , Crysler CS , Ninan NS , Abad MC , Spurlino JC , Desjarlais RL , Kervinen J , Neeper MP , Bayoumy SS , Williams R , Deckman IC , Dasgupta M , Reed RL , Huebert ND , Tomczuk BE , Moriarty KJ (- 7)
Ref: Bioorganic & Medicinal Chemistry Lett,
16 :123, 2006 :
PubMed Abstract PubMedSearch: Qiao 2006 Bioorg.Med.Chem.Lett 16 123 PubMedID: 16236500 Gene_locus related to this paper: human-DPP4 Inhibitor(s) related to this paper: JNH ,
p-Iodo-Phe-Pyr-CN Abstract
The discovery, SAR, and X-ray crystal structure of novel biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported.
        
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Citations formats
Qiao L, Baumann CA, Crysler CS, Ninan NS, Abad MC, Spurlino JC, Desjarlais RL, Kervinen J, Neeper MP, Bayoumy SS, Williams R, Deckman IC, Dasgupta M, Reed RL, Huebert ND, Tomczuk BE, Moriarty KJ (2006) Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitorsBioorganic & Medicinal Chemistry Lett 16 : 123-8 Qiao L, Baumann CA, Crysler CS, Ninan NS, Abad MC, Spurlino JC, Desjarlais RL, Kervinen J, Neeper MP, Bayoumy SS, Williams R, Deckman IC, Dasgupta M, Reed RL, Huebert ND, Tomczuk BE, Moriarty KJ (2006) Bioorganic & Medicinal Chemistry Lett 16 : 123-8