We describe the incorporation of a bicyclo[1.1.1]pentane moiety within two known LpPLA2 inhibitors to act as bioisosteric phenyl replacements. An efficient synthesis to the target compounds was enabled with a dichlorocarbene insertion into a bicyclo[1.1.0]butane system being the key transformation. Potency, physicochemical, and X-ray crystallographic data were obtained to compare the known inhibitors to their bioisosteric counterparts, which showed the isostere was well tolerated and positively impacted on the physicochemical profile.
Measom ND, Down KD, Hirst DJ, Jamieson C, Manas ES, Patel VK, Somers DO (2017) Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor ACS Med Chem Lett8: 43-48
Measom ND, Down KD, Hirst DJ, Jamieson C, Manas ES, Patel VK, Somers DO (2017) ACS Med Chem Lett8: 43-48
