Title: LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1 Liu Y, Wang LL, Chen S, Zong ZH, Guan X, Zhao Y Ref: J Cell Mol Med, 22:3955, 2018 : PubMed
To investigate the expression, role and mechanism of action of long non-coding RNA (lncRNA) ABHD11-AS1 in endometrial carcinoma. The expression of lncRNA ABHD11-AS1 was quantified by qRT-PCR in human endometrial carcinoma (n = 89) and normal endometrial tissues (n = 27). LncRNA ABHD11-AS1 was stably overexpressed or knocked-down in endometrial carcinoma cell lines to examine the cellular phenotype and expression of related molecules. Compared to normal endometrial tissue, lncRNA ABHD11-AS1 was significantly overexpressed in endometrial carcinoma. Overexpression of lncRNA ABHD11-AS1 promoted the proliferation, G1-S progression, invasion and migration of endometrial cancer cells; inhibited apoptosis; up-regulated cyclin D1, CDK1, CDK2, CDK4, Bcl-xl and VEGFA; and down-regulated p16, while ABHD11-AS1 down-regulation has the opposite effect. RNA pull down demonstrated that lncRNA ABHD11-AS1 binds directly to cyclin D1. Knockdown of cyclin D1 can reverse the effect of ABHD11-AS1. Overexpression of lncRNA ABHD11-AS1 increased the tumorigenicity and up-regulated cyclin D1 in an in vivo model of endometrial cancer in nude mice. LncRNA ABHD11-AS1 functions as an oncogene to promote cell proliferation and invasion in endometrial carcinoma by positively targeting cyclin D1.
Liu Y, Wang LL, Chen S, Zong ZH, Guan X, Zhao Y (2018) LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1 J Cell Mol Med22: 3955-3964
Liu Y, Wang LL, Chen S, Zong ZH, Guan X, Zhao Y (2018) J Cell Mol Med22: 3955-3964