Paper Report for: Kurukulasuriya_2006_Bioorg.Med.Chem.Lett_16_6226 Reference
Title: Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors
Kurukulasuriya R , Rohde JJ , Szczepankiewicz BG , Basha F , Lai C , Jae HS , Winn M , Stewart KD , Longenecker KL and von Geldern TW <3 more author(s)>
Kurukulasuriya R , Rohde JJ , Szczepankiewicz BG , Basha F , Lai C , Jae HS , Winn M , Stewart KD , Longenecker KL , Lubben TW , Ballaron SJ , Sham HL , von Geldern TW (- 3)
Ref: Bioorganic & Medicinal Chemistry Lett,
16 :6226, 2006 :
PubMed Abstract PubMedSearch: Kurukulasuriya 2006 Bioorg.Med.Chem.Lett 16 6226 PubMedID: 17010607 Gene_locus related to this paper: ratno-dpp4 Inhibitor(s) related to this paper: LIR Abstract
A series of xanthine mimetics containing 5,5 and 5,6 heterocycle fused imidazoles were synthesized as dipeptidyl peptidase IV inhibitors. Compound 7 is potent (h-DPPIV K(i)=2nM) and exhibits excellent selectivity and no species specificity against rat and human enzymes. The X-ray structure confirms that the binding mode of 7 to rat DPPIV is similar to the parent xanthines.
        
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Citations formats
Kurukulasuriya R, Rohde JJ, Szczepankiewicz BG, Basha F, Lai C, Jae HS, Winn M, Stewart KD, Longenecker KL, Lubben TW, Ballaron SJ, Sham HL, von Geldern TW (2006) Xanthine mimetics as potent dipeptidyl peptidase IV inhibitorsBioorganic & Medicinal Chemistry Lett 16 : 6226-30 Kurukulasuriya R, Rohde JJ, Szczepankiewicz BG, Basha F, Lai C, Jae HS, Winn M, Stewart KD, Longenecker KL, Lubben TW, Ballaron SJ, Sham HL, von Geldern TW (2006) Bioorganic & Medicinal Chemistry Lett 16 : 6226-30