Paper Report for: Guillou_2000_Bioorg.Med.Chem.Lett_10_637
Reference
Title: Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts Guillou C, Mary A, Renko DZ, Gras E, Thal C Ref: Bioorganic & Medicinal Chemistry Lett, 10:637, 2000 : PubMed
The syntheses, the anticholinesterase activities and structure-activity relationships of homodimeric (3a-c) and heterodimeric (6a-c) alkylene linked bis-galanthamine are reported. Compounds 6b-c were found to be more potent than galanthamine and tacrine in inhibiting AChE.
Guillou C, Mary A, Renko DZ, Gras E, Thal C (2000) Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts Bioorganic & Medicinal Chemistry Lett10: 637-9
Guillou C, Mary A, Renko DZ, Gras E, Thal C (2000) Bioorganic & Medicinal Chemistry Lett10: 637-9