Paper Report for: Grant_2001_Cell.Mol.Neurobiol_21_783
Reference
Title: Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase Grant AD, Shapira M, Soreq H Ref: Cellular Molecular Neurobiology, 21:783, 2001 : PubMed
The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), and a novel previously unidentified gene (PIX), co-oriented with ACHE. Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission.
        
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Grant AD, Shapira M, Soreq H (2001) Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase Cellular Molecular Neurobiology21: 783-97
Grant AD, Shapira M, Soreq H (2001) Cellular Molecular Neurobiology21: 783-97