Paper Report for: Grandic_2012_Bioorg.Med.Chem_20_1659
Reference
Title: Binding and permeabilization of lipid bilayers by natural and synthetic 3-alkylpyridinium polymers Grandic M, Zovko A, Frangez R, Turk T, Sepcic K Ref: Bioorganic & Medicinal Chemistry, 20:1659, 2012 : PubMed
Naturally occurring 3-alkylpyridinium polymers from the marine sponge Reniera sarai are membrane-active compounds exerting a selective cytotoxicity towards non small cell lung cancer cells, and stable transfection of nucleated mammalian cells. In view of their possible use as chemotherapeutics and/or transfection tools, three poly-APS based synthetic compounds were tested on their activity using natural and artificial lipid membranes. The tested compounds were found to be very stable over a wide range of temperature, ionic strength, and pH, and to prefer the solid-ordered membrane state. Their membrane-damaging activity increases with the length of their alkyl chains and the degree of polymerization.
Grandic M, Zovko A, Frangez R, Turk T, Sepcic K (2012) Binding and permeabilization of lipid bilayers by natural and synthetic 3-alkylpyridinium polymers Bioorganic & Medicinal Chemistry20: 1659-64
Grandic M, Zovko A, Frangez R, Turk T, Sepcic K (2012) Bioorganic & Medicinal Chemistry20: 1659-64