Paper Report for: Anderson_1985_Neurosci.Lett_54_123
Reference
Title: Effects of fasciculin 2, an anticholinesterase polypeptide from green mamba venom, on neuromuscular transmission in mouse diaphragm preparations Anderson AJ, Harvey AL, Mbugua PM Ref: Neuroscience Letters, 54:123, 1985 : PubMed
Fasciculin 2, a polypeptide from green mamba (Dendroaspis angusticeps) venom, causes an increase in the twitch response of mouse phrenic nerve-hemidiaphragm preparations to indirect stimulation. Intracellular recording reveals that fasciculin 2 augments neuromuscular transmission by increasing the amplitude and duration of endplate potentials. Its action is not reversed by washing. Interactions with neostigmine confirm that fasciculin 2 acts as an anticholinesterase. It has no presynaptic actions on transmitter release or postsynaptic receptor blocking actions. On chicken muscle preparations, fasciculin 2 has no anticholinesterase actions. Because of this selectivity and its apparent irreversibility, fasciculin 2 should be useful in characterizing different forms of acetylcholinesterase.
Anderson AJ, Harvey AL, Mbugua PM (1985) Effects of fasciculin 2, an anticholinesterase polypeptide from green mamba venom, on neuromuscular transmission in mouse diaphragm preparations Neuroscience Letters54: 123-8
Anderson AJ, Harvey AL, Mbugua PM (1985) Neuroscience Letters54: 123-8