Hemila_1994_Biochim.Biophys.Acta_1210_249

Reference

Title : Hormone-sensitive lipase is closely related to several bacterial proteins, and distantly related to acetylcholinesterase and lipoprotein lipase: identification of a superfamily of esterases and lipases - Hemila_1994_Biochim.Biophys.Acta_1210_249
Author(s) : Hemila H , Koivula TT , Palva I
Ref : Biochimica & Biophysica Acta , 1210 :249 , 1994
Abstract :

We have sequenced a gene from Bacillus acidocaldarius which encodes an open reading frame (ORF3) of 310 amino acids. The ORF3 was found to be related to the mammalian hormone-sensitive lipase (HSL). Searching the protein data base revealed five other bacterial proteins related to the HSL. Upon further sequence comparisons this HSL-group was found to be related to the family of carboxylesterases, and to a family of lipases (lipoprotein, hepatic and pancreatic lipases). The evolutionary relationship of these serine-dependent hydrolytic enzymes has not been studied previously, and it has not been known that these proteins belong to the same superfamily. Finally, the alignment of the HSL with the bacterial proteins allowed us to infer the location of the hormone-sensitive regulatory domain of the HSL-protein.

PubMedSearch : Hemila_1994_Biochim.Biophys.Acta_1210_249
PubMedID: 8280778

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Citations formats

Hemila H, Koivula TT, Palva I (1994)
Hormone-sensitive lipase is closely related to several bacterial proteins, and distantly related to acetylcholinesterase and lipoprotein lipase: identification of a superfamily of esterases and lipases
Biochimica & Biophysica Acta 1210 :249

Hemila H, Koivula TT, Palva I (1994)
Biochimica & Biophysica Acta 1210 :249