| Title : Fold prediction and comparative modeling of Bdm1: a probable alpha\/beta hydrolase associated with hot water epilepsy - Bhaduri_2003_J.Mol.Model_9_3 |
| Author(s) : Bhaduri A , Krishnaswamy L , Ullal GR , Panicker MM , Sowdhamini R |
| Ref : J Mol Model , 9 :3 , 2003 |
|
Abstract :
Hot water epilepsy (HWE) is a benign and rare form of reflex epilepsy that occurs most commonly in humans. Bdm1 is one of the proteins whose mRNA transcript is overexpressed during HWE in a rat model. We show, by sequence analysis and fold recognition methods, that Bdm1 has strong structural similarities to alpha/beta hydrolases like the thioesterases. A three-dimensional model derived by comparative modeling methods allowed the search for catalytic residues using a flexible functional template characteristic of these enzymes. We predict that Bdm1 might be regulated by homocysteine levels by means of direct participation in degradation pathways. |
| PubMedSearch : Bhaduri_2003_J.Mol.Model_9_3 |
| PubMedID: 12638006 |
| Gene_locus related to this paper: ratno-ndr4 |
| Gene_locus | ratno-ndr4 |
| Family | Ndr_family |
Bhaduri A, Krishnaswamy L, Ullal GR, Panicker MM, Sowdhamini R (2003)
Fold prediction and comparative modeling of Bdm1: a probable alpha\/beta hydrolase associated with hot water epilepsy
J Mol Model
9 :3
Bhaduri A, Krishnaswamy L, Ullal GR, Panicker MM, Sowdhamini R (2003)
J Mol Model
9 :3