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Mutation Report for: Y337W_human-ACHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|Y337W
Torpedo number|330
Comment|p.Y337W Tyr337Trp (p.Y368W Tyr368Trp in primary sequence with 31 amino-acids signal peptide) Signal transduction, Substrate activation at low Ph inhibition at high Ph
Kinetic parameters|none

    Title: Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite
    Masson P, Schopfer LM, Bartels CF, Froment MT, Ribes F, Nachon F, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1594:313, 2002 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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