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Mutation Report for: Y337A/F338A_human-ACHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|Y337A/F338A
Torpedo number|330,331//331//330
Comment|p.Y337A/F338A Tyr337Ala/Phe338Ala (p.Y368A/F369A Tyr368Ala/Phe369Ala in primary sequence with 31 amino-acids signal peptide) Oxime interaction;non-aging catalytic bioscavenger
Kinetic parameters|none

    Title: Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase
    Kovarik Z, Macek Hrvat N, Kalisiak J, Katalinic M, Sit RK, Zorbaz T, Radic Z, Fokin VV, Sharpless KB, Taylor P
    Ref: Toxicol Appl Pharmacol, 372:40, 2019 : PubMed


    Title: HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants
    Macek Hrvat N, Zunec S, Taylor P, Radic Z, Kovarik Z
    Ref: Chemico-Biological Interactions, 259:148, 2016 : PubMed


    Title: Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes
    Kovarik Z, Macek Hrvat N, Katalinic M, Sit RK, Paradyse A, Zunec S, Musilek K, Fokin VV, Taylor P, Radic Z
    Ref: Chemical Research in Toxicology, 28:1036, 2015 : PubMed


    Title: Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging
    Cochran R, Kalisiak J, Kucukkilinc TT, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovarik Z and Taylor P <2 more author(s)>
    Ref: Journal of Biological Chemistry, 286:29718, 2011 : PubMed


    Title: Functional requirements for the optimal catalytic configuration of the AChE active center
    Shafferman A, Barak D, Kaplan D, Ordentlich A, Kronman C, Velan B
    Ref: Chemico-Biological Interactions, 157-158:123, 2005 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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