Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Succinylthiocholine binding Higher Km and kcat Masson_1997_Biochemistry_36_2266 || Peripheral Anionic site interraction 70\/332 Masson_1999_Biochim.Biophys.Acta_1433_281
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Succinylthiocholine binding
Torpedo_number : 334
Kinetic Parameter : No kinetic parameter
News : No news
Comment : p.Y332F Tyr332Phe (p.Y360F Tyr360Phe in primary sequence with 28 amino-acids signal peptide) Peripheral Anionic site\;interraction 70(98)\/332(360)
| Title : Interaction between the peripheral site residues of human butyrylcholinesterase, D70 and Y332, in binding and hydrolysis of substrates - Masson_1999_Biochim.Biophys.Acta_1433_281 |
| Author(s) : Masson P , Xie W , Froment MT , Levitsky V , Fortier PL , Albaret C , Lockridge O |
| Ref : Biochimica & Biophysica Acta , 1433 :281 , 1999 |
| Abstract : Masson_1999_Biochim.Biophys.Acta_1433_281 |
| ESTHER : Masson_1999_Biochim.Biophys.Acta_1433_281 |
| PubMedSearch : Masson_1999_Biochim.Biophys.Acta_1433_281 |
| PubMedID: 10446378 |
| Title : Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase - Masson_1997_Biochemistry_36_2266 |
| Author(s) : Masson P , Legrand P , Bartels CF , Froment MT , Schopfer LM , Lockridge O |
| Ref : Biochemistry , 36 :2266 , 1997 |
| Abstract : Masson_1997_Biochemistry_36_2266 |
| ESTHER : Masson_1997_Biochemistry_36_2266 |
| PubMedSearch : Masson_1997_Biochemistry_36_2266 |
| PubMedID: 9047329 |